The last incident involved two people from Springfield and one from Northampton in a fatal motorcyle accident on the Massachusetts Turnpike in Natick.
Springfield firefighters extinguished a basement fire at 110 Lorimer St. in Indian Orchard early Saturday morning. Three people were injured, one seriously.Four people with ties to Western Massachusetts died in incidents over the weekend.
Matthew Babin, 43, went into cardiac arrest after a fire in Springfield's Indian Orchard section sent three other people to the hospital for smoke inhalation.
Five of the six people who were inside the 1-story, ranch-style home at the time of the incident managed to escape, but firefighters found a 43-year-old man lying on the living room floor.
As of Monday morning, no arrests had been announced in the shooting death of a 26-year-old man in Holyoke, later identified as Oscar Castro.
Police said the man apparently was chased to the corner of Lyman and High streets, where he was fatally wounded outside the Clover Cafe at 104 High St.
In Southwick, a 22-year-old man, who also had not been publicly identified as of Monday morning, died following an early morning swimming incident in the Congamond Lakes.
The 22-year-old man .... jumped from a boat into Middle Pond - the largest of Congamond's three ponds - around 1 a.m. Sunday and hasn't been seen since then, according to law enforcement officials investigating the incident.
And finally, 40-year old Dewayne C. Holmes, 40, of Springfield, was killed Sunday morning in a motorcycle accident on the Massachusetts Turnpike in Natick, according to the Metro West Daily News.
Police said Holmes was driving a 2008 Suzuki GSX 1300 in the far right lane beside a 2006 Suzuki GSX 1300 motorcycle driven by Robert Cephas, 39, of Springfield, when the two bikes made contact, the Framingham-based newspaper reported.
State police said both drivers were thrown from their bikes, with one of the motorcycles hitting a 2007 Infiniti FX driven by a Northborough man in the far right travel lane.