UMass chemical engineer Michael Henson is one of three researchers who received a four-year, $1.8 million grant from the National Institutes of Health to study circadian rhythm.
AMHERST -- Michael A. Henson, a chemical engineer at the University of Massachusetts, sees first-hand what happens when the body's clock is interrupted.
His wife, Jennifer Dohrmann, works in the emergency room at Baystate Franklin Medical Center in Greenfield. Some days she works at 7 in the morning and some days her shifts start at 11 at night.
"The body's not capable of (adapting). People feel chronically exhausted. I certainly see the effect," he said.
Henson is one of three researchers who received a four-year, $1.8 million grant from the National Institutes of Health to study circadian rhythms, the 24-hour cycle of biological processes in humans, other animals and plants.
Awarded in the fall, the grant is a continuation of previous awards from the NIH in 2006 and 2012.
Most people can adjust easily to the one-hour time change that happens twice a year around Daylight Saving Time. Traveling across the country or overseas often requires a longer adjustment period. But Henson said the most pressing circadian rhythm problems arise for those who work different shifts, and that's the focus of his team's work.
People working varied shifts is "not as uncommon as people think," he said. For instance, hospitals have varied shifts because it's hard to get people to work every overnight shift. "You have to distribute the pain," he said.
Henson's role in the study will be to create mathematical models that simulate how brain cells interact. Yannis Kevrekidis of Princeton University will develop advanced simulation methods for solving the models, while Erik Herzog of Washington University will conduct and monitor experiments with mice.
With the mice, Henson said, the researchers will observe the effects of shifting the light-dark cycle from day to day.
The researchers hope to have some results in a couple of years, then make recommendations to a sleep disorders clinic to test out, Henson said. There might be light or drug therapies that could help people, he said.
Some people working different shifts take benzodiazepines to help them sleep, he said. If they gain a better understanding how the biological clock works, the researchers could determine the best time for people to take these drugs.
Henson said he was as delighted to receive the addition grant.
"It's a big achievement," he said. "It's very competitive. They're very hard to get. It's very exciting."